Drug targets in the autonomic nervous system essay

For example, the sympathetic system will cause sphincters in the digestive tract to contract, limiting digestive propulsion, but the parasympathetic system will cause the contraction of other muscles in the digestive tract, which will try to push the contents of the digestive system along.

The somatic nervous system consists of nerves that exit to the skin and muscles and is concerned in wakeful actions. Structure and function of the cardiac muscle The cardiac muscle is an involuntary striated muscle which is composed of individual uninucleate cells that are connected to each other by intercalated discs.

A chemical that the body produces to interact with those receptors is called an endogenous chemical, whereas a chemical introduced to the system from outside is an exogenous chemical. In this essay the following things about the autonomic nervous system will be considered; its organization, how it affects the musculature of the body smooth and cardiac muscle and what neurotransmitters are released.

The ACh receptors on these neurons are of the nicotinic type, meaning that they are ligand-gated ion channels. When the neurotransmitter released from the preganglionic fiber binds to the receptor protein, a channel opens to allow positive ions to cross the cell membrane.

In the case of sympathetic neurons the postganglionic axons are relatively long. This information is added together before messages are sent out to the effectors. It functions mechanically and incessantly, without attentive attempt, to innervate smooth muscle, cardiac muscle, and glands.


Parasympathetic pathways also have a critical role in focusing the eye and modifying pupil diameter. Cholinergic drugs are also called parasympathomimetics because their effect mimics the effect of parasympathetic nerve stimulation.

Let us answer some questions now. The two types of neurons sympathetic and somatic then diverge as the preganglionic neurons enter the white rami communicantes its white as the axons of the preganglionic neurons are myelinated which then lead to the axons entering the nearest sympathetic paraverterbal ganglion.

The cerebrum receives sensory information through the receptors of sense organs. Let us start with cerebrum which is in the forebrain. In terms of function, the parasympathetic nervous system is concerned primarily with conservation and restoration of function.

The opposing signals to the heart would both depolarize and hyperpolarize the heart cells that establish the rhythm of the heartbeat, likely causing arrhythmia. Autonomic innervation, irrespective of whether it belongs to the parasympathetic or the sympathetic nervous system, consists of a myelinated preganglionic fiber which forms a synapse with the cell body of a non-myelinated second neuron termed post-ganglionic fiber.

Adrenergic neuron terminals synthesize noradrenaline, store it in vesicles and release it to effector cells upon stimulation of the nerve.

Broad Autonomic Effects

There are several drugs affecting the autonomic nervous system which, for a better understanding of specific drugs, are classified into groups. Ganglia of both divisions are activated equally by the drug.

The work of central nervous system is to direct incoming messages to the motor neurons that are connected to the part of the body which will respond to a stimulus. By using the central nervous system, a person can vary his behaviour according to the changing situations. The second pathway involves the axons from the postganglionic neurons making synapses with the target tissues which then lead to their innervations.

The autonomic nervous system has two parts, the sympathetic division and the parasympathetic division. Similarly, cerebrum has motor areas from which instructions are sent to muscles to do various types of jobs.

Pharmacodynamics As mentioned earlier it has two types of actions: In comparison to the sympathetic ganglia the terminal ganglia are more peripherally located and are more widely distributed.

Along with constricting the pupil through the smooth muscle of the iris, pilocarpine will also cause the ciliary muscle to contract.

These ganglionic neurons form four cranial nerves; oculomotor nerve, facial nerve, glossopharyngeal nerve and vagus nerve.

Like the adrenergic agents, phenylephrine is effective in dilating the pupil, known as mydriasis Figure The forebrain consists mainly of cerebrum. Like the sympathetic nervous system, the preganglionic parsympathetic motor neurons make synaptic contact with the postganglionic neurons but these are found in the terminal ganglia, which are located within the wall of the target organs.

They primarily work as an antagonist to the adrenergic receptors. If we pick up a very hot plate in the kitchen without knowing that it is very hotthen our reflex action produced by the spinal cord alone says that we should pull away our hand so that our hand is saved from burns.

The cerebellum coordinates smooth body movements such as walking, dancing, riding a bicycle and picking up a pencil, etc. However a key difference between the two muscles is that for cardiac muscle, contraction is not initiated by neurons, instead it is caused by the sinoatrial node which is responsible for generating spontaneous and periodic contractions.

Short essay on The Autonomic Nervous System

Pairs of cranial nerves arise from the brain. It functions as a neurotransmitter at all cholinergic sites in the body; because of its unique pharmacokinetic properties, it has never been used in medical therapeutics; the discussion which follows is for academic exercise.Question A year old male patient presents to your clinic with a complaint of swollen ankles for the past 2 weeks.

He has a history of hypertension, which has been well controlled for 1 year with a combination of clonidine and a diuretic. His blood pressure today is /92 mm Hg, which is significantly higher Continue reading "Drugs Affecting The Autonomic Nervous System".

Autonomic Nervous System Essay Sample

DRUGS ACTING ON THE AUTONOMIC NERVOUS SYSTEM. INTRODUCTION. The nervous system controls all the major functions of the body. It is divided into central and peripheral nervous systems. The peripheral nervous system includes the somatic and autonomic nervous systems which control voluntary and involuntary functions respectively.

Essay on ANS Nervous System Words | 6 Pages & function of the Autonomic Nervous System Introduction: The organs of our body are controlled by many systems in order to function correctly and efficiently in order to survive within the environment we live in.

These include the heart, stomach and intestines and other vital organs and body systems. Drugs that Affect the Autonomic System. Previous Next. By the end of this section, you will be able to: List the classes of pharmaceuticals that interact with the autonomic nervous system; Other drugs are sympatholytic because they block adrenergic activity and cancel the sympathetic influence on the target organ.

Drugs that act on. The Autonomic Nervous System is a widespread system of nerves that innervates, with the exception of skeletal muscle, nearly every process in the body.

This Autonomic Nervous System (ANS) is a completely unconscious process which is responsible for maintaining homeostasis, as well as having many other functions such as control of digestion.

The nerves of the autonomic nervous system are attached to the smooth muscles of the various internal organs of the human body like head, heart, blood vessels, alimentary canal, lungs, kidneys, urinary bladder, glands and skin, etc.

Drug targets in the autonomic nervous system essay
Rated 5/5 based on 68 review